Cryopreservation of human spermatozoa is a widely used technique in the assisted reproduction technology laboratory for the storage of gametes for later use, for the fertility preservation and for sperm donation programs. Cryopreservation can cause damage to membrane, cytoskeletal, acrosome and increased oxidative stress, sperm DNA damage and transcriptome changes. To assess the impact of...Read More
This single-centre retrospective observational study included 6919 ICSI cycles from 2013 to 2022. The primary outcome was the assessment of oocyte fertilization, measured in terms of the rate of formation of two-pronuclear (2PN), 3PN and 1PN zygotes. Secondary outcomes were blastulation, cumulative positive β-human chorionic gonadotrophin test and clinical pregnancy rates. Relationships between ejaculatory abstinence...Read More
OBJECTIVEPrevious studies demonstrated that female body mass index (BMI) is associated with alterations in embryo morphokinetics as seen by time-lapse microscopy (TLM). Here we examined the effect of paternal BMI on embryo morphokinetics. MATERIALS AND METHODS445 IVF cycles from 320 unique patients were studied. From these cycles, 1314 embryos were produced. Embryos were cultured and...Read More
OBJECTIVEIntracytoplasmic sperm injection (ICSI) is a technique which involves aspiration of the oocyte membrane after mechanically penetrating the zona pellucida. This process might result in an increase in the internal pressure of the oocyte and a possible degeneration of the oocyte membrane. PIEZO-ICSI is a technique which uses a piezoelectric actuator to maintain the microdrilling...Read More
Purpose Semen parameters are subjected to within-individual variability over time. The driving factors for this variability are likely multi-factorial, with healthier lifestyle associated with better semen quality. The extent in which variations in individual’s lifestyle contributes to within-individual semen variability is unknown. In healthy men from the general population, semen quality and associated lifestyle factors...Read More
Sperm that were immobile became active after just 20 seconds of ultrasound exposure in a lab experiment that may help boost the success of fertility treatment. Exposing immobile sperm to ultrasound waves gets them moving, a lab study has shown. Sperm that don’t move properly are a key cause of infertility, as it is harder...Read More
Are the prospective reproductive outcomes in RPL couples related to sperm DNA fragmentation index (DFI) measured by SCSA, morphology and concentration at referral? Design A prospective cohort study including 95 couples seen between 01/04/2018 and 01/12/2019 at the tertiary Copenhagen RPL Unit, Copenhagen University Hospital, Rigshospitalet and Hvidovre Hospital, Denmark. The couples had experienced three...Read More
The role of sperm DNA fragmentation index (DFI) in investigating fertility, embryonic development,and pregnancy is of academic interest. However, there is ongoing controversy regarding the impactof DFI on pregnancy outcomes and the safety of offspring in the context of Assisted ReproductiveTechnology (ART). Sperm DFI has an impact on both miscarriage rates and birth weight in...Read More
Are the prospective reproductive outcomes in RPL couples related to sperm DNA fragmentation index (DFI) measured by SCSA, morphology and concentration at referral? Design A prospective cohort study including 95 couples seen between 01/04/2018 and 01/12/2019 at the tertiary Copenhagen RPL Unit, Copenhagen University Hospital, Rigshospitalet and Hvidovre Hospital, Denmark. The couples had experienced three...Read More
💃🕺 Check out this lively video featuring some groovy sperm breaking it down.Science meets rhythm in the most unexpected ways! 🎉 . Hey! If you found this post interesting or useful, you can help us get even better by subscribing to our newsletter. Just write your email and you’ll have the latest fertility news. Thank...Read More
Sperm Tracer is a unique AI technological software that supports fertility experts and embryologists to evaluate, in real-time, the best sperm for ICSI procedures.
Each embryo carries 50% of the genetic information of an oocyte and 50% of a sperm. Every single sperm participating with 50% of the DNA cargo of the embryo, could play a detrimental role for the embryo itself and its quality.
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