Background The recommended ejaculatory abstinence (EA) period prior to semen collection varies between regulatory bodies. The World Health Organization recommends 2–7 days, whereas the European Society of Human Reproduction and Embryology and the Nordic Association for Andrology recommend 3–4 days. Prolonged epididymal storage of spermatozoa may increase sperm DNA fragmentation, and impair subsequent embryo development...Read More

BackgroundStress has been negatively associated with reproductive outcomes, including poor semen quality in men; however, the molecular mechanisms underlying these associations remain poorly understood. ObjectivesThis study aimed to evaluate the association between perceived stress and sperm DNA methylation patterns in men undergoing infertility treatment. Materials and MethodsThe study was conducted on 169 men attending the...Read More

How Does Sperm Tracer Work? Understanding AI-Assisted Sperm Selection The technology is designed to provide real-time information about sperm characteristics while keeping the embryologist at the center of the decision-making process. What does Sperm Tracer analyze? Sperm Tracer is designed to assess important sperm characteristics, including: Motility Morphology Movement patterns Individual sperm characteristics It also...Read More

This retrospective study evaluated whether sperm DNA fragmentation (SDF), measured by DNA fragmentation index (DFI), predicts IVF outcomes in 124 couples undergoing IVF with PGT-A (Preimplantation Genetic Testing for Aneuploidy) between 2015 and 2023. SDF was assessed using the Halosperm kit and categorized into low (≤15%, n=81), medium (15–30%, n=34), and high (≥30%, n=9) DFI...Read More

Can AI Improve Sperm Selection for ICSI? When couples undergo ICSI, one sperm is carefully selected by an embryologist and injected directly into the egg. This makes sperm selection an important part of the laboratory process. Traditionally, embryologists assess sperm by observing characteristics such as movement and appearance under a microscope. Advances in artificial intelligence...Read More

Objective:To evaluate the laboratory performance of a standardized gradient-based sperm preparation system designed to improve progressive motility recovery during density gradient centrifugation for intrauterineinsemination (IUI). Design:Retrospective, multicenter laboratory cohort study. Patients:A total of 13,416 semen samples processed for IUI. Interventions:Comparison between a conventional density gradient centrifugation method and a standardized gradient-based preparation system (RS system)...Read More

How Does ICSI Help When Sperm Motility Is Low? Sperm motility refers to how well sperm move. When sperm have reduced motility, they may have greater difficulty reaching and fertilizing an egg naturally. Depending on the severity and underlying cause, fertility specialists may recommend treatments such as ICSI. What is low sperm motility? Motility is...Read More

Can AI Help Find Sperm in Azoospermia and mTESE Samples? Azoospermia means that no sperm are detected in a man’s ejaculate. Although this can be a challenging diagnosis, the absence of sperm in semen does not always mean that sperm cannot be found elsewhere in the reproductive system. In some cases, sperm retrieval procedures such...Read More

In animals, mature sperm are stored in males before ejaculation and sometimes in females before fertilization. Sperm storage provides evolutionary advantages; however, storage can also cause sperm deterioration owing to post-meiotic sperm senescence (PMSS). Yet, the extent of such deterioration, the mechanisms driving it and its fitness consequences remain poorly understood. We perform a meta-...Read More

One-third of infertile couples struggle to conceive despite normal examination and tests. For men, semen analysis is the only widely-adopted diagnostic tool to assess male infertility. However, it is unable to detect abnormal sperm function or accurately predict pregnancy except in cases of complete absence of sperm. Sperm function tests (SFT) could help by directing...Read More