Cryopreservation of human spermatozoa is a widely used technique in the assisted reproduction technology laboratory for the storage of gametes for later use, for the fertility preservation and for sperm donation programs. Cryopreservation can cause damage to membrane, cytoskeletal, acrosome and increased oxidative stress, sperm DNA damage and transcriptome changes. To assess the impact of...Read More
This single-centre retrospective observational study included 6919 ICSI cycles from 2013 to 2022. The primary outcome was the assessment of oocyte fertilization, measured in terms of the rate of formation of two-pronuclear (2PN), 3PN and 1PN zygotes. Secondary outcomes were blastulation, cumulative positive β-human chorionic gonadotrophin test and clinical pregnancy rates. Relationships between ejaculatory abstinence...Read More
The present meta-analysis is the largest to date to assess the impact of VR on Leydig cell and Sertoli cell function using a before-after analysis for uncontrolled studies, and using data from patients with unrepaired varicoceles or healthy patients without varicocele as controls. VR was found to increase and restore to normality serum levels of...Read More
This study offers valuable insights into the structural architecture of the mammalian egg-sperm fusion synapse, shedding light on the role of specific proteins in fertilization. The significance of the findings lies in the potential identification of a pentameric complex involved in gamete fusion by AlphaFold Multimer. A crucial event in sexual reproduction is when haploid sperm and...Read More
The global fall in male fertility is a complicated process driven by a variety of factors, including environmental exposure, lifestyle, obesity, stress, and aging. The availability of assisted reproductive technology (ART) has allowed older couples to conceive, increasing the average paternal age at first childbirth. Advanced paternal age (APA), most often considered male age ≥40,...Read More
OBJECTIVEPrevious studies demonstrated that female body mass index (BMI) is associated with alterations in embryo morphokinetics as seen by time-lapse microscopy (TLM). Here we examined the effect of paternal BMI on embryo morphokinetics. MATERIALS AND METHODS445 IVF cycles from 320 unique patients were studied. From these cycles, 1314 embryos were produced. Embryos were cultured and...Read More
OBJECTIVEIntracytoplasmic sperm injection (ICSI) is a technique which involves aspiration of the oocyte membrane after mechanically penetrating the zona pellucida. This process might result in an increase in the internal pressure of the oocyte and a possible degeneration of the oocyte membrane. PIEZO-ICSI is a technique which uses a piezoelectric actuator to maintain the microdrilling...Read More
ObjectiveTo investigate possible associations between serum antimüllerian hormone (AMH) concentration and semen quality in infertile men. Studies investigating the associations between serum AMH concentration and semen quality in infertile men have shown conflicting results. DesignInfertile men were included during screening for participation in the First in Treating Male Infertility Study, a double-blinded, placebo-controlled, 1:1, single-center...Read More
Purpose Semen parameters are subjected to within-individual variability over time. The driving factors for this variability are likely multi-factorial, with healthier lifestyle associated with better semen quality. The extent in which variations in individual’s lifestyle contributes to within-individual semen variability is unknown. In healthy men from the general population, semen quality and associated lifestyle factors...Read More
Sperm that were immobile became active after just 20 seconds of ultrasound exposure in a lab experiment that may help boost the success of fertility treatment. Exposing immobile sperm to ultrasound waves gets them moving, a lab study has shown. Sperm that don’t move properly are a key cause of infertility, as it is harder...Read More
Sperm Tracer is a unique AI technological software that supports fertility experts and embryologists to evaluate, in real-time, the best sperm for ICSI procedures.
Each embryo carries 50% of the genetic information of an oocyte and 50% of a sperm. Every single sperm participating with 50% of the DNA cargo of the embryo, could play a detrimental role for the embryo itself and its quality.
If you believe you are among the pioneers, we may be able to help you reach even higher.
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