The role of sperm DNA fragmentation index (DFI) in investigating fertility, embryonic development,
and pregnancy is of academic interest. However, there is ongoing controversy regarding the impact
of DFI on pregnancy outcomes and the safety of offspring in the context of Assisted Reproductive
Technology (ART).
Sperm DFI has an impact on both miscarriage rates and birth weight in assisted reproductive technology. The smooth fitting curve analysis reveals a positive correlation between miscarriage rates and DFI, while a
negative correlation is observed between birth weight and DFI.
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