Recurrent pregnancy loss (RPL) is a condition affecting up to 5% of couples. We conducted a systematic review and meta-analysis (SRMA) to synthesize the evidence on the relationship between seminal oxidative stress (OS) and RPL. This study aimed to evaluate whether seminal OS markers differ between men from couples experiencing RPL and those from fertile...Read More
Sperm and pusher eukaryotic cells achieve locomotion through a complex interaction between their flagellar movement and the surrounding fluid. The flagellar waveform arises from a balance of dynein-driven cytoskeletal forces, passive structural resistance, and hydrodynamic drag. However, the underlying mechanisms of cell-fluid interactions remain poorly understood due to the limitations of current measurement techniques. Here,...Read More
According to these extensive Danish data, if your total motile sperm count is <5 × 106/ml you can expect to live for 77.6 years, whereas if you are lucky enough to possess a count of >120 × 106/ml, your life expectancy will increase to 80.3 years. This is encouraging for those so endowed, although they will still be dying 3 years before...Read More
Male infertility and semen quality have been suggested to be markers of morbidity and thus mortality, but the role of underlying disease present at time of semen quality evaluation has not been thoroughly assessed. The aim of this study was to determine the association between semen quality and mortality, and to assess the impact of...Read More
The objective of this study was to evaluate the impact of basic semen analysis parameters, assessed according to WHO-2021 criteria, as well as paternal BMI and paternal age on embryological and clinical ICSI outcomes among couples undergoing preimplantation genetic testing for aneuploidy (PGT-A). Our main goal is to provide IVF professionals with information about the...Read More
Does advanced male partner’s age impact live birth rates (LBRs) in IVF treatment when female partner’s age is factored in? Advanced paternal age is associated with declining sperm parameters, impaired embryo development, compromised pregnancy outcomes, and abnormalities in the offspring in IVF/ICSI cycles. However, data on the interaction between maternal and paternal age on IVF...Read More
Cryopreservation of human spermatozoa is a widely used technique in the assisted reproduction technology laboratory for the storage of gametes for later use, for the fertility preservation and for sperm donation programs. Cryopreservation can cause damage to membrane, cytoskeletal, acrosome and increased oxidative stress, sperm DNA damage and transcriptome changes. To assess the impact of...Read More
This single-centre retrospective observational study included 6919 ICSI cycles from 2013 to 2022. The primary outcome was the assessment of oocyte fertilization, measured in terms of the rate of formation of two-pronuclear (2PN), 3PN and 1PN zygotes. Secondary outcomes were blastulation, cumulative positive β-human chorionic gonadotrophin test and clinical pregnancy rates. Relationships between ejaculatory abstinence...Read More
The present meta-analysis is the largest to date to assess the impact of VR on Leydig cell and Sertoli cell function using a before-after analysis for uncontrolled studies, and using data from patients with unrepaired varicoceles or healthy patients without varicocele as controls. VR was found to increase and restore to normality serum levels of...Read More
This study offers valuable insights into the structural architecture of the mammalian egg-sperm fusion synapse, shedding light on the role of specific proteins in fertilization. The significance of the findings lies in the potential identification of a pentameric complex involved in gamete fusion by AlphaFold Multimer. A crucial event in sexual reproduction is when haploid sperm and...Read More
Sperm Tracer is a unique AI technological software that supports fertility experts and embryologists to evaluate, in real-time, the best sperm for ICSI procedures.
Each embryo carries 50% of the genetic information of an oocyte and 50% of a sperm. Every single sperm participating with 50% of the DNA cargo of the embryo, could play a detrimental role for the embryo itself and its quality.
If you believe you are among the pioneers, we may be able to help you reach even higher.
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